客服热线:400-901-9800          客服QQ:4009019800          技术答疑     技术支持     质量反馈     联系我们
首页 > www.long8.com > 一抗 > 产品信息
Rabbit Anti-CD112 antibody (bs-2679R)
订购热线:400-901-9800
订购邮箱:sales@bioss.com.cn
订购传真:010-58129612
技术支持:support@bioss.com.cn
说明书:50ul  100ul  200ul
50ul/780.00元
100ul/1380.00元
200ul/2200.00元
大包装/询价

产品编号bs-2679R
英文名称CD112
中文名称细胞粘附分子CD112抗体
别    名Nectin-2; Nectin2; Nectin 2; CD 112; CD112; CD112 antigen; Herpes virus entry mediator B; Herpes virus entry protein B; Herpesvirus entry mediator B; Herpesvirus entry protein B; Hve B; HveB; Poliovirus receptor like 2; Poliovirus receptor related 2 (herpesvirus entry mediator B); Poliovirus receptor related 2; Poliovirus receptor related protein 2; Poliovirus receptor-related protein 2; PRR 2; PRR2; PVRL 2; PVRL2; PVRL2_HUMAN; PVRR 2; PVRR2.  
规格价格50ul/780元购买    100ul/1380元购买    200ul/2200元购买    大包装/询价
说 明 书50ul  100ul  200ul
研究领域肿瘤  免疫学  神经生物学  细胞粘附分子  细胞表面分子  内皮细胞  
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Cow, Horse, 
产品应用ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 Flow-Cyt=1μg /test ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量56kDa
细胞定位细胞膜 
性    状Lyophilized or Liquid
浓    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human CD112:251-350/538 <Extracellular>
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMedPubMed
产品介绍background:
Nectin 2 is a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. Can form trans-heterodimers with PVRL3/nectin-3.

Function:
Probable cell adhesion protein.

Subunit:
Can form trans-heterodimers with PVRL3/nectin-3. Interacts with CD226. Binds with low affinity to TIGIT. Interacts with herpes simplex virus 1 (HHV-1) mutant Rid1, herpes simplex virus 1 (HHV-2) and pseudorabies virus (PRV) envelope glycoprotein D; functions as an entry receptor for these viruses.

Subcellular Location:
Cell membrane; Single-pass type I membrane protein.

Tissue Specificity:
Ubiquitous.

Similarity:
Belongs to the nectin family.
Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
Contains 1 Ig-like V-type (immunoglobulin-like) domain.

SWISS:
Q92692

Gene ID:
5819

Database links:

Entrez Gene: 5819 Human

Entrez Gene: 19294 Mouse

Entrez Gene: 308417 Rat

Omim: 600798 Human

SwissProt: Q92692 Human

SwissProt: P32507 Mouse

Unigene: 655455 Human

Unigene: 4341 Mouse

Unigene: 203297 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

细胞粘附分子Nectin-2(CD112)是一种同源性非钙依赖型的CAM,属免疫球蛋白超家族,由nectin-1、nectin-2、nectin-3组成,广泛存在于肿瘤、正常细胞,神经细胞、内皮细胞等,CD112也是单纯疱疹病毒(HSV-1和HSV-2)的受体,具有同型或异型细胞粘附活性.在多发性硬化中呈现高表达。
产品图片
Blank control(blue): U937(fixed with 2% paraformaldehyde (10 min)).
Primary Antibody:Rabbit Anti-CD112 antibody(bs-2679R), Dilution: 1μg in 100 μL 1X PBS containing 0.5% BSA;
Isotype Control Antibody: Rabbit IgG(orange) ,used under the same conditions );
econdary Antibody: Goat anti-rabbit IgG-PE(white blue), Dilution: 1:200 in 1 X PBS containing 0.5% BSA.
版权所有 2016-2020 www.bioss.com.cn 龙8娱乐-www.long8.com-龙8国际平台【官方唯一平台】 京ICP备05066980号 京公网安备110107000727号
通过国际质量管理体系ISO9001:2008 GB/T19001-2008认证    编号:00115Q211807R1M/1100