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Rabbit Anti-SLCO3A1/AP Conjugated antibody (bs-11802R-AP)
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说 明 书:100ul  
100ul/2980.00元
大包装/询价
产品编号bs-11802R-AP
英文名称Anti-SLCO3A1/AP
中文名称碱性磷酸酶(AP)标记的可溶性载质转运蛋白3A1抗体
别    名OATP-D; OATP D; OATP RP3; OATP3A1; OATPD; OATPRP3; Organic anion transporter polypeptide related protein 3; Organic anion transporting polypeptide D; PGE1 transporter; SLC21A11; Sodium independent organic anion transporter D; Solute carrier family 21 (organic anion transporter) member 11; Solute carrier family 21 member 11; Solute carrier organic anion transporter family member 3A1; FLJ40478; SO3A1_HUMAN.  
规格价格100ul/2980元购买        大包装/询价
说 明 书100ul  
研究领域神经生物学  信号转导  生长因子和激素  
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Dog, Pig, Cow, Horse, Zebrafish, 
产品应用IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量77kDa
性    状Lyophilized or Liquid
浓    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human SLCO3A1/OATP-D
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍background:
The organic anion transporter family of proteins mediate hepatic uptake of cardiac glycosides. OATP-D is a 710 amino acid member of the organic anion transporter protein family. As a multi-pass membrane protein, OATP-D mediates the Na+-independent transport of vasopressin, prostaglandins (PG) E1 and E2, thyroxine (T4), deltorphin II and other organic anions, but not estrone-3-sulfate, DPDPE, taurocholate, DHEAS or digoxin. OATP-D is ubiquitously expressed with highest levels present in leukocytes and spleen. OATP-D is expressed as four isoforms produced by alternative splicing events.

Function:
SLCO3A1 mediates the Na+-independent transport of organic anions such as estrone-3-sulfate. It mediates transport of prostaglandins (PG) E1 and E2, thyroxine (T4), deltorphin II, BQ-123 and vasopressin, but not DPDPE (a derivative of enkephalin lacking an N-terminal tyrosine residue), taurocholate, digoxin nor DHEAS. There are four named isoforms.

Subcellular Location:
Membrane; Multi-pass membrane protein.

Tissue Specificity:
Ubiquitous. Highly expressed in spleen and leukocytes. Generally the expression of isoform 1 is higher than that of isoform 2. Isoform 2 is particularly abundant in testis and brain. In testis, isoform 1 is detected in spermatogonia at different stages and absent from Sertoli cells, while isoform 2 is present in both (at protein level). Expressed in the choroid plexus epithelium, isoform 1 being localized at the basolateral membrane and isoform 2 at the apical one, as well as in the subapical intracellular vesicular compartments. Differential expression of both isoforms is also observed in other brain region: isoform 1 is very abundant in the gray matter of the frontal cortex, but is not associated with neuronal cell bodies. Not detected in the white matter. In contrast, isoform 2 is associated with neuronal bodies and axons in both the gray and the white matters of the frontal cortex.

Similarity:
Belongs to the organo anion transporter (TC 2.A.60) family.
Contains 1 Kazal-like domain.

Database links:

Entrez Gene: 28232 Human

Entrez Gene: 108116 Mouse

Entrez Gene: 140915 Rat

Omim: 612435 Human

SwissProt: Q9UIG8 Human

SwissProt: Q8R3L5 Mouse

SwissProt: Q99N02 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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