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Rabbit Anti-Tmem18/AP Conjugated antibody (bs-11799R-AP)
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说 明 书:100ul  
100ul/2980.00元
大包装/询价
产品编号bs-11799R-AP
英文名称Anti-Tmem18/AP
中文名称碱性磷酸酶(AP)标记的跨膜蛋白18抗体
别    名DKFZp434C1714; TMEM18; TMM18_HUMAN; Transmembrane protein 18.  
规格价格100ul/2980元购买        大包装/询价
说 明 书100ul  
研究领域神经生物学  内分泌病  
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, 
产品应用WB=1:50-200 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量16kDa
性    状Lyophilized or Liquid
浓    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human Tmem18
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍background:
TMEM18 is a 140 amino acid multi-pass membrane protein that localizes to the nuclear membrane and is expressed in the brain. TMEM18 functions as a cell migration modulator which enhances the glioma-specific migration ability of neural precursor and neural stem cells.Overexpression of TMEM18 increases migration of human and murine neural stem cells, whereas knockdown of TMEM18 mRNA reduces cellular migration. Two specific single nucleotide polymorphisms (SNPs) within the TMEM18 gene locus known as rs6548238 and rs756131 have been linked to obesity susceptibility.

Function:
Cell migration modulator which enhances the glioma-specific migration ability of neural stem cells (NSC) and neural precursor cells (NPC).

Subunit:
Forms homooligomers, independently of the DNA-binding domain.

Subcellular Location:
Cytoplasm. Nucleus membrane; Multi-pass membrane protein.

Similarity:
Belongs to the TMEM18 family.

Database links:
UniProtKB/Swiss-Prot: Q96B42.2

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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