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Rabbit Anti-Tetanus toxin light chain/AP Conjugated antibody (bs-10155R-AP)
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说 明 书:100ul  
100ul/2980.00元
大包装/询价
产品编号bs-10155R-AP
英文名称Anti-Tetanus toxin light chain/AP
中文名称碱性磷酸酶(AP)标记的破伤风毒素轻链抗体
别    名Tentoxylysin;Tetanus toxin chain L;Tetanus toxin light chain; TETX_CLOTE.  
规格价格100ul/2980元购买        大包装/询价
说 明 书100ul  
研究领域
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Clostridium tetani E88
产品应用IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量50kDa
性    状Lyophilized or Liquid
浓    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from Clostridium tetani E88 Tetanus toxin light chain
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍background:
Tetanus toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that catalyzes the hydrolysis of the 76-Gln-|-Phe-77 bond of synaptobrevin-2. The precursor polypeptide is subsequently cleaved to yield subchains L and H. These remain linked by a disulfide bridge and are non-toxic after separation.

Function:
Tetanus toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that catalyzes the hydrolysis of the '76-Gln-|-Phe-77' bond of synaptobrevin-2.

Subunit:
The precursor polypeptide is subsequently cleaved to yield subchains L and H. These remain linked by a disulfide bridge and are non-toxic after separation.

Subcellular Location:
Secreted.

Similarity:
Belongs to the peptidase M27 family.

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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