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Rabbit Anti-phospho-LRRK2(Thr1410)/AP Conjugated antibody (bs-11786R-AP)
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说 明 书:100ul  
100ul/2980.00元
大包装/询价
产品编号bs-11786R-AP
英文名称Anti-phospho-LRRK2(Thr1410)/AP
中文名称碱性磷酸酶(AP)标记的磷酸化富亮氨酸重复激酶2抗体
别    名LRRK2 (phospho T1410); LRRK2 (phospho Thr410); p-LRRK2 (Thr410); Dardarin; Leucine rich repeat kinase 2; LRRK 2; LRRK-2; LRRK2; PARK 8; PARK8; ROCO 2; ROCO-2; ROCO2; Leucine-rich repeat serine/threonine-protein kinase 2; Dardarin; LRRK2_HUMAN; augmented in rheumatoid arthritis 17; AURA17; Leucine rich repeat kinase 2; RIPK7.  
规格价格100ul/2980元购买        大包装/询价
说 明 书100ul  
产品类型磷酸化抗体 
研究领域细胞生物  神经生物学  信号转导  
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, 
产品应用IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量286kDa
性    状Lyophilized or Liquid
浓    度1mg/ml
免 疫 原KLH conjugated synthesised phosphopeptide derived from human LRRK2 around the phosphorylation site of Thr1410
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍background:
LRRK2 (Dardarin) is encoded by the gene LRRK2. Genetic mutations of LRRK2 have been linked to Parkinsonism and synucleinopathies. LRRK2 belongs to the ROCO protein family and includes a protein kinase domain of the MAPKKK class and several other major functional domains.

Function:
May play a role in the phosphorylation of proteins central to Parkinson disease. Phosphorylates PRDX3. May also have GTPase activity.

Subunit:
Interacts with PARK2. Interacts with PRDX3. Interacts with TPCN2.

Subcellular Location:
Cytoplasm. Membrane. Mitochondrion. Localized in the cytoplasm and associated with cellular membrane structures. Associates with the mitochondrial outer membrane.

Tissue Specificity:
Expressed throughout the adult brain, but at a lower level than in heart and liver. Also expressed in placenta, lung, skeletal muscle, kidney and pancreas. In the brain, expressed in the cerebellum, cerebral cortex, medulla, spinal cord occipital pole, frontal lobe, temporal lobe and putamen. Expression is particularly high in brain dopaminoceptive areas.

DISEASE:
Defects in LRRK2 are the cause of Parkinson disease type 8 (PARK8) [MIM:607060]. A slowly progressive neurodegenerative disorder characterized by bradykinesia, rigidity, resting tremor, postural instability, neuronal loss in the substantia nigra, and the presence of neurofibrillary MAPT (tau)-positive and Lewy bodies in some patients.

Similarity:
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
Contains 12 LRR (leucine-rich) repeats.
Contains 1 protein kinase domain.
Contains 1 Roc domain.

Database links:
UniProtKB/Swiss-Prot: Q5S007.2

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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